Publics The Company Various sectors of the company are taken into consideration when formulating marketing plans. Each department is interconnected and they come together to form the company portion of the marketing microenvironment. These departments work together to discover customer needs and create customer value.
Personalized therapy which specifically focuses on targeting cancer cells is now considered as a standard therapy in cancer management.
Though personalized therapy can reduce side effects of normal cell damages by specific targeting, most tumors eventually acquire resistance to target specific drugs by genetic or epigenetic changes. Thus, additional efforts have been made to overcome the limitations of personalized therapy.
Tumor heterogeneity induces characteristic changes in their therapeutic responses. Local factors such as blood supply and tissue acidosis differently influence the tumor cells and cells in the tumor microenvironment.
Previous therapies have focused on only tumor cells, but tumor cells and their microenvironmental cells should be considered as therapeutic targets 1.
Since malignant progression followed by distal dissemination can reflect either genetic or epigenetic cellular heterogeneity or both, cellular heterogeneity between primary and metastatic lesions could be also considered in the design of more efficient cancer therapies 2.
Epigenetic heterogeneity can also contribute to differentiation-related or drug resistance-related changes in cancer cells, in which DNA is hypomethylated to generate genetic instability and disturb gene expression. Cellular heterogeneity can even occur within one tumor lesion. In deeper area of the tumor, most cells exit from the cell cycle, and only cancer cells located on the exterior of the tumor mass undergo cell cycling.
Because different clinical presentations subsequently affect therapeutic response and prognosis, successful tumor therapy requires deep understanding of tumor heterogeneity. Thyroid carcinoma is a good example to discuss tumor heterogeneity and different clinical presentations in each patient, or even in the different lesions from same patient.
Thyroid cancer is the most common cancer in Korean women, and almost cases are differentiated thyroid cancer DTC.
Radioiodines have been widely used for the management of DTC and the molecular mechanism of iodine selectivity is related to the sodium iodide symporter NIS. Accumulation of radioiodine is dependent on the expression of membrane NIS, which is a molecular target of radioiodine whole body scans and I therapy.
Moreover, different NIS expression was observed in different tumor lesions even in one patient. Half of patients with multiple lymph node metastases showed different NIS expression between the different lesions. We found that tumor detectability of radioiodine scan is higher in relatively well differentiated tumor than in less differentiated tumor, but tumor detectability of 18F-FDG PET is reversed 5.
This kind of molecular imaging can characterize the heterogeneity of DTC tumor in different lesions, and guide the most proper management. Though in vitro molecular diagnostics can analyze the differences in tumor lesions, most of them require tissue sample and are difficult for direct application in clinic.
However, molecular imaging modalities easily visualize the heterogeneous features of different tumor lesions. According to different characteristics among tumor lesions in one patient, more efficient treatment and suitable management should be taken.Despite the uncertainties facing the global economy, certain trends are leslutinsduphoenix.com world will become smaller, more aged, more city-focused, more cautious and more polarised between the rich and poor.
Micro environment factors, are factors close to a business that have a direct impact on its business operations and success. Before deciding corporate strategy businesses should carry out a full analysis of their micro environment. Abstract.
The metastatic potential of non-small cell lung cancer (NSCLC) cells has been shown to be associated with the tumor microenvironment. Cancer-associated fibroblasts (CAFs) are a major component of the tumor microenvironment, regulating tumor cell function by secreting growth factors, chemokines, and extracellular matrix (ECM).
1 Samsung Biomedical Research We report that direct physical contact between these two cell types contributes to distinctive microenvironmental impacts on NSCLC progression. cell culture inserts with porous membrane has often been used to investigate how the diffusible factors that CAFs secrete affect the motility of cancer cells.
Environmental factors can play a major part in a company's marketing leslutinsduphoenix.comnmental factors can include social, ecological, political, cultural, technological, and ethical issues.
PepsiCo can face all these issues because they are a global company. Many of these issues can affect PepsiCo's marketing plan even in different areas of the United States. This section will focus on the Macro environment of Samsung and I will explain how the external factors affect the company by looking in their opportunities and threats also go through PESTEL analysis.